Our clinical trials

Taking part in research helps improve health care and can benefit people on the Sunshine Coast and around the world. If you are thinking about joining a clinical trial, talk to your doctor or health care provider to find out if it is right for you.

In Research

Current clinical trials at Sunshine Coast Health

Find our current clinical trials below, select the title to learn more about a particular study. Each study has specific requirements, and only people who meet these requirements can take part. You should also review the general eligibility information and learn more about participating in a clinical trial. It is important to talk with your doctor or health care provider too, they can help you decide if a study is suitable for you.

Department	Title	Conditions	Identifier
Cardiology	Can adding blood flow restriction exercise training to cardiac rehabilitation, improve fitness and vascular health?	Coronary artery disease, Cardiovascular, Rehabilitation	BFRinCR
Cardiology	Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity	Heart failure, Obesity, Cardiovascular	MARITIME-HF
Cardiology	A Feasibility Study Implant of the WiSE® CRT System With an Intracardiac Pacemaker to Achieve Totally Leadless CRT	Heart failure, Coronary heart disease, Cardiovascular	TLC-AU
Emergency	FEBCON-ED Study: Does advice to give regular antipyretics for children presenting with a FEBrile CONvulsion to the Emergency Department reduce the rate of seizure reoccurrence within the same febrile illness?	Febrile convulsions, Neurological	FEBCON-ED
Gastroenterology	A Prospective Randomised Controlled Trial of Adults with Perianal Fistulising Crohn’s Disease and Optimised Therapeutic Infliximab Levels: PROACTIVE Trial	Crohn’s disease, Inflammatory bowel disease	PROACTIVE Study
Gastroenterology	Study of Tilpisertib Fosmecarbil in Participants with Moderately to Severely Active Ulcerative Colitis.	Inflammatory bowel disease, Ulcerative colitis	PALEKONA GS-US_457-6411
Gastroenterology	Safety and Tolerability of CLB-4000 in Subjects with Chronic Hepatitis B: Randomised cohort	Chronic Hepatitis B	CLB-4000-1-001
General Medicine	Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Atrial Fibrillation Occurring Transiently With Stress	Stroke, Atrial fibrillation, Cardiovascular	ASPIRE-AF trial
General Surgery	Can a new standard of radiology reporting help improve diagnosis of pancreatic cancer?	Pancreatic cancer	SCANPatient Study
Haematology	Frailty-stratified, randomised controlled Bayesian adaptive trial of bortezomib versus lenalidomide in transplant-ineligible myeloma (TI-NDMM) – the FRAIL-M study	Multiple myeloma	The Frail-M Study
Haematology	A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)	Multiple myeloma	SUCCESSOR-1
Haematology	A Real World Effectiveness Study of Pegcetacoplan in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)	Blood, Paroxysmal nocturnal, Hemoglobinuria	PEGCET COMPLETE
Haematology	Phase 3 Study of Teclistamab in Combination With Lenalidomide and Teclistamab Alone Versus Lenalidomide Alone in Participants With Newly Diagnosed Multiple Myeloma as Maintenance Therapy Following Autologous Stem Cell Transplantation	Multiple myeloma	MajesTEC-4; EMN30
Haematology	A Randomized, Multicenter, Phase III Trial Comparing Treatment With R-mini-CHOP With R-mini-CHP + Polatuzumab Vedotin in Patients With Diffuse Large Cell B Cell Lymphoma	Lymphoma (non Hodgkin's lymphoma)	NHL39 Polar Bear
Haematology	A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared with Placebo Plus Zanubrutinib in Adults with Relapsed/Refractory Mantle Cell Lymphoma	Mantle cell lymphoma, B cell lymphoma	BGB-11417-302
Haematology	A Study to Learn About the Study Medicine Called Elranatamab in People with Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment with an Anti-CD38 Antibody and Lenalidomide)	Multiple myeloma	MAGNETISMM-32
Haematology	A Study to Investigate Progression-Free Survival with Sonrotoclax Plus Obinutuzumab or Sonrotoclax Plus Rituximab Compared with Venetoclax Plus Rituximab Treatment in Patients with Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma	Chronic lymphocytic leukemia, Small lymphocytic lymphoma	BGB-11417-303
Haematology	A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma	Chronic lymphocytic leukemia, Small lymphocytic lymphoma	BGB-16673-304
Haematology	A Study to Learn How Safe and How Well Linvoseltamab Works Compared to Standard Treatment in Adult Patients with Multiple Myeloma Who Are Not Eligible for Transplant	Multiple myeloma	EMN39
Haematology	Study of Navtemadlin add-on to Ruxolitinib in JAK Inhibitor-Naïve Patients With Myelofibrosis Who Have a Suboptimal Response to Ruxolitinib	Myelofibrosis	POIESIS (KRT-232-115)
Haematology	Bleximenib in Combination With Standard Induction and Consolidation Therapy Followed by Maintenance for Treatment of Patients With Acute Myeloid Leukemia (AML)	Acute myeloid leukemia	HOVON 181
Hepatology	A Long-Term Study of Elafibranor in Adult Participants with Primary Biliary Cholangiti	Primary Biliary Cholangitis (PBC)	ELFIDENCE CLIN-60190-454
Hepatology	A randomised controlled trial of Standard of Care versus RadioAblaTion in Early Stage HepatoCellular Carcinoma	Early hepatocellular carcinoma	SOCRATES
Radiation Oncology	A randomised controlled trial of Standard of Care versus RadioAblaTion in Early Stage HepatoCellular Carcinoma	Early hepatocellular carcinoma	SOCRATES
Hepatology	Multicentre, randomized trial of immunotherapy prior to surgical resection for early-stage hepatocellular carcinoma	Hepatocellular carcinoma, Liver cancer	DEFINERx050
Hepatology	A Study to Evaluate the Safety and Tolerability of Pumitamig Alone or In Combination with Ipilimumab in Participants with First-Line Advanced or Unresectable Hepatocellular Carcinoma (HCC)	Hepatocellular carcinoma, cancer	ROSETTA HCC-206
Intensive Care	Balanced Multi-Electrolyte Solution Versus Saline Trial for Diabetic KetoAcidosis	Diabetic ketoacidosis	BEST-DKA
Intensive Care	A Platform Trial for Gram Negative Bloodstream Infections	Gram-negative bacteremia	BALANCE+
Medical Oncology	Duration of Anti-PD-1 Therapy in Metastatic Melanoma	Metastatic melanoma	STOP-GAP
Medical Oncology	Phase II randomised controlled trial of patient‐specific adaptive versus continuous abiraterone or enzalutamide in metastatic castration‐resistant prostate cancer	Prostate cancer	ANZadapt ANZUP 2101
Medical Oncology	A Study of First-Line Olomorasib and Pembrolizumab with or without Chemotherapy in Patients with Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer	Carcinoma, Neoplasm metastasis	SUNRAY-01
Medical Oncology	Phase III, Open-label, Study of First-line Dato-DXd in Combination with Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC = 50%) and Without Actionable Genomic Alterations	Lung cancer	TROPIAN-Lung10
Medical Oncology	Paxalisib Plus Olaparib or Pembrolizumab/Chemotherapy in Advanced Breast Cancer	Breast Cancer	PAXPLUS-ABC
Medical Oncology	A Study to Evaluate the Benefit of Adding Durvalumab After Chemotherapy, Durvalumab and Surgery in Patients with Early-stage, Operable, Non-small Cell Lung Cancer	Lung cancer	ADOPT-Lung
Medical Oncology	Study of Olomorasib in Combination with Standard of Care in Participants with Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer	Carcinoma	SUNRAY-02
Medical Oncology	This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People with Non-small Cell Lung Cancer with High Levels of PD-L1	Lung cancer	Be6A Lung-02
Medical Oncology	A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People with Colorectal Cancer	Colon adenocarcinoma, Rectal adenocarcinoma	KANDLELIT-012
Medical Oncology	A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants with Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer	Lung cancer	CO45042 KRASCENDO 2
Medical Oncology	A Study to Test Inavolisib Treatment in Participants with Metastatic Castration-Resistant Prostate Cancer	Prostate cancer	CO45813 INAVO-PC
Medical Oncology	A Study to Compare the Combination of Navlimetostat (BMS-986504) with Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants with Homozygous MTAP Deletion	Lung cancer	Mountain TAP-29
Medical Oncology	A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination with Chemotherapy Versus Bevacizumab in Combination with Chemotherapy in Participants with Previously Untreated, Unresectable, or Metastatic Colorectal Cancer	Metastatic colorectal cancer	ROSETTA CRC-203 (CA266-0003)
Medical Oncology	A Study to Learn About the Study Medicine Called PF-08634404 in Combination with Chemotherapy in Adult Participants with Locally Advanced or Metastatic Non-Small Cell Lung Cancer	Lung cancer	Protocol: C6461001 SYMBIOTIC-01
Medical Oncology	A Study to Learn About the Study Medicine Called PF-08634404 in Combination with Chemotherapy in Adult Participants with Extensive-Stage Small Cell Lung Cance	Lung cancer	C6461004
Neonatology	A pragmatic stepped wedge cluster randomised implementation trial assessing a quality improvement program to increase delayed cord clamping for preterm infants	Delayed cord clamping, Premature birth pre-37weeks	WAMM
Neonatology	Surfactant Administration by Supraglottic Airway for Preterm Infants with Respiratory Distress Syndrome	Respiratory distress syndrome of prematurity	SURFSUP
Neonatology	Testing if Glue Can Safely Secure Intravenous (IV) Lines in Newborns	Catheter complications in neonates, Skin	PENGUIN
Neurosciences	Study of ARO-DUX4 in Adult and Adolescent Patients with Facioscapulohumeral Muscular Dystrophy Type 1	Facio scapulo Humeral dystrophy, Musculoskeletal, Genetics	ARO-DUX4
Neurosciences	Study of ARO-DM1 in Subjects with Type 1 Myotonic Dystrophy	Myotonic dystrophy, Musculoskeletal	ARO-DM1
Neurosciences	Efficacy and Safety of a New Formulation of Oral Cladribine Compared with Placebo in Participants with Generalized Myasthenia Gravis	Generalised myasthenia gravis, Musculoskeletal, Inflammatory and immune system	MYCLAD
Neurosciences	First in Human (FIH) Study of ALN-SOD in Adult Participants with Amyotrophic Lateral Sclerosis Associated with Mutation in the SOD1 Gene (SOD1-ALS	Amyotropic Lateral Sclerosis (ALS), Genetics, Mutation in the superoxide dismutase-1 (SOD1) gene	ALN-SOD-ALS-2351
Neurosciences	A Clinical Study to Investigate the Effect of Oral Neflamapimod on Motor Recovery After Acute Ischaemic Stroke	Stroke	RESTORE; CRV024-NFD-601
Neurosciences	Clinical trial of anti-Epstein-Barr virus therapies for the prevention of progression in multiple sclerosis	Multiple Sclerosis	STOP-MS
Neurosciences	Low dose combinations to improve stroke outcomes.	Hypertension, Hypercholesterolaemia, Stroke, Ischaemic attack	LOTUS
Obstetrics and Gynaecology	Reducing operative birth for fetal distress in women with small or poorly grown infants using Sildenafil Citrate - The RidStress 2 Randomised Controlled Trial	Birth asphyxia, Small for gestational age infants	RIDSTRESS 2
Obstetrics and Gynaecology	OPTIMISing induction of labour care: oral misoprostol versus balloon dilatation within a stratified inpatient to outpatient setting	Induction of labour, Cervical ripening	OptiMis-IO
Orthopaedics	Reverse or Anatomical replacement for Painful Shoulder Osteoarthritis, Differences between Interventions	Shoulder osteoarthritis, Musculoskeletal, Surgical	RAPSODI-AUS
Paediatrics	Preventing infusate injuries throughout a child’s hospitalisation	Extravasation injuries	PATCH Study
Paediatrics	Preventing adverse events during paediatric cancer treatment: A multi-site hybrid randomised, controlled trial of catheter lock solutions	Paediatric cancer, Central vascular access device (CVAD) related adverse events	CLOCK Study
Physiotherapy	Inspiratory muscle training for Intensive Care patients requiring prolonged mechanical ventilation	Prolonged muscle weakness, Prolonged mechanical ventilation, Inspiratory muscle training , Critical illness, Post ICU syndrome	INSPIRE BEYOND ICU
Radiation Oncology	Functional magnetic resonance imaging guided radiation therapy dose escalation in head and neck cancer	Head and neck cancer	FIGURE-rad HNC
Radiation Oncology	Functional magnetic resonance imaging guided radiation therapy dose escalation in head and neck cancer	Head and neck cancer	FIGURE-pall FIGR pall
Radiation Oncology	Functional imaging-guided radiotherapy dose escalation in rectal adenocarcinoma: a feasibility study	Rectal cancer	FIGR Rectal
Radiation Oncology	High dose palliative radiotherapy in patients with metastatic malignancy who cannot or will not have standard of care such as chemotherapy or other drug treatment	Metastatic cancer, Metastatic malignancy, Oesophageal cancer, Pancreatic cancer, Head and neck cancer, Cutaneous squamous cell carcinoma, Colorectal cancer, Bladder cancer, Triple negative breast cancer, Lung cancer, Skin cancer	HD-PRiMe
Radiation Oncology	Functional imaging-guided radiotherapy short course dose escalation in rectal adenocarcinoma: a feasibility study	Rectal cancer	FIGR-Short
Renal	Randomised Evaluation of Sodium Dialysate Levels on Vascular Events	End-stage kidney disease	RESOLVE
Renal	Better Evidence and Translation for Calciphylaxis	Calciphylaxis	BEAT-Calci
Renal	Combined Dose-Finding and CV Outcomes Study with CSL300 (Clazakizumab) in Adult Subjects with ESKD Undergoing Dialysis	Cardiovascular disease in patients with ESKD	CSL3_230100 (POSIBIL6ESKD)
Renal	A Randomised Controlled Clinical Trial to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients with Severe Chronic Kidney Disease.	Chronic kidney disease, Renal transplant failure, Heart failure, Kidney failure	RENAL LIFECYCLE
Renal	The Chronic kidney disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect	Chronic kidney diseases	CAPTIVATE
Renal	A Study Evaluating Persistence of the Immune Response of the Adjuvanted Respiratory Syncytial Virus (RSV) Vaccine and the Safety and Immune Response Following Revaccination in Adults 18 Years of Age and Above Who Received Lung or Kidney Transplant	Respiratory syncytial virus infections, Infection	Protocol 224083 RSV
Respiratory	Randomised controlled trial of diagnosis and safety in bronchoscopic versus computed tomography (CT) guided biopsy for peripheral lung nodules	Lung cancer, Peripheral lung nodule, Respiratory	REBUTT
Respiratory	Ceftolozane/Tazobactam Continuous Intravenous Infusion given in an Outpatient Setting to treat Infective Exacerbations of Cystic Fibrosis and Bronchiectasi	Bronchiectasis, Cystic fibrosis, Genetics and inherited disorders, Respiratory	CERTAIN
Respiratory	The Australasian Malignant Pleural Effusion: Topical Antibiotic Prophylaxis for Infections of Indwelling Pleural Catheters in Patients with Malignant Pleural Effusions	Malignant pleural effusion, Respiratory, Cancer, Infection	AMPLE-4
Respiratory	Dose Range Finding, Efficacy, and Safety Study of Nebulized CSL787 in Adults with Non-cystic Fibrosis Bronchiectasis (NCFB)	Non-cystic fibrosis bronchiectasis	CSL787_2001
Respiratory	Rademikibart Add-on Treatment of an Acute COPD Exacerbation	COPD Acute exacerbation, Respiratory	CBP-201-207
Respiratory	Study to Evaluate the Safety, Pharmacology and Efficacy of WIN378 in Adults with Moderate or Severe Asthma	Asthma, Respiratory	WB-2101
Trauma	Fibrinogen Early In Severe Trauma Study	Haemorrhagic shock, Coagulopathy, Skin, Blood, Cardiovascular	FIESTY II

Last updated: September 2026